Papillary renal neoplasm with reverse polarity may be a novel renal cell tumor entity with low malignant potential.

ABSTRACT:

Aims

This study retrospectively investigated the morphological, immunohistochemical and molecular genetic features of papillary renal neoplasm with reverse polarity (PRNRP), a recently described renal tumor.

Methods and results

Eleven cases of PRNRP were collected, and 16 cases of type I and 9 cases of type II papillary renal cell carcinoma were included as a control series. Pathological features were evaluated based on HE staining and immunohistochemistry. KRAS exon 2 and BRAF V600E mutations were detected by Real-time PCR and Sanger sequencing. Fluorescence in situ hybridization was conducted for identification of chromosomal abnormalities. Hemosiderin deposition was found in a small amount of tumor cells in 6 cases. Multifocal or patchy necrosis (5/11), small focal invasi

SUBMITTER: Yang T 

PROVIDER: S-EPMC9404576 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature