Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems.

ABSTRACT: Activating innate immunity in a controlled manner is necessary for the development of next-generation therapeutics. Adjuvants, or molecules that modulate the immune response, are critical components of vaccines and immunotherapies. While small molecules and biologics dominate the adjuvant market, emerging evidence supports the use of immunostimulatory polymers in therapeutics. Such polymers can stabilize and deliver cargo while stimulating the immune system by functioning as pattern recognition receptor (PRR) agonists. At the same time, in designing polymers that engage the immune system, it is important to consider any unintended initiation of an immune response that results in adverse immune-related events. Here, we highlight biologically derived and synthetic polymer scaffolds, as well

SUBMITTER: Weiss AM 

PROVIDER: S-EPMC9404695 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature