Refining the <i>Camelus dromedarius</i> Myostatin Gene Polymorphism through Worldwide Whole-Genome Sequencing.

ABSTRACT: Myostatin (MSTN) is a highly conserved negative regulator of skeletal muscle in mammals. Inactivating mutations results in a hyper-muscularity phenotype known as "double muscling" in several livestock and model species. In Camelus dromedarius, the gene structure organization and the sequence polymorphisms have been previously investigated, using Sanger and Next-Generation Sequencing technologies on a limited number of animals. Here, we carried out a follow-up study with the aim to further expand our knowledge about the sequence polymorphisms at the myostatin locus, through the whole-genome sequencing data of 183 samples representative of the geographical distribution range for this species. We focused our polymorphism analysis on the ±5 kb upstream and downstream region of th

SUBMITTER: Bruno S 

PROVIDER: S-EPMC9404819 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature