Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function.

ABSTRACT: Glycosylation is a fundamental cellular process affecting human development and health. Complex machinery establishes the glycan structures whose heterogeneity provides greater structural diversity than other post-translational modifications. Although known to present spatial and temporal diversity, the evolution of glycosylation and its role at the tissue-specific level is poorly understood. In this study, we combined genome and transcriptome profiles of healthy and diseased tissues to uncover novel insights into the complex role of glycosylation in humans. We constructed a catalogue of human glycosylation factors, including transferases, hydrolases and other genes directly involved in glycosylation. These were categorized as involved in N-, O- and lipid-linked glycosylation, glypiation,

SUBMITTER: Sobral D 

PROVIDER: S-EPMC9404854 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature