Expression of Key Factors of the Hippo Signaling Pathway in Yak (Bos grunniens) Mammary Gland.

ABSTRACT: Due to its rich nutritional value, yak milk is an important food source in the alpine pastoral areas. However, yaks have a low milk yield. The Hippo pathway participates in cell proliferation and organ development. We aimed to determine the regulatory mechanism of this pathway in yak mammary cells. A greater understanding of how the expression of its essential genes influence the reproductive cycle could lead to improvements in lactation performance. The expression levels of the key genes MST1, LATS1, YAP1, and TEAD1 were detected by quantitative real-time PCR, Western blotting, and immunohistochemistry during the growth, lactation, and dry periods (GP, LP and DP, respectively). The MST1 and LATS1 mRNA and protein expression level was highest during GP and lowest during LP. The YAP1 and TE

SUBMITTER: Du P 

PROVIDER: S-EPMC9404922 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature