Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality.

ABSTRACT:

Background

Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD). This has been attributed to abnormal HDL function in CKD.

Methods

In this study, we analyzed the association of genetic markers for kidney function with cholesterol efflux capacity as one of the major HDL functions, as well as with cardiovascular mortality, in 2469 patients of the Ludwigshafen Risk and Cardiovascular Health Study who all underwent coronary angiography.

Results

A genetic score of 53 SNPs associated with GRF and the uromodulin SNP rs12917707 were inversely correlated with cholesterol efflux capacity. This was in l

SUBMITTER: Ritsch A 

PROVIDER: S-EPMC9404976 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature