Oxo-Carotenoids as Efficient Superoxide Radical Scavengers.

ABSTRACT: Oxo-carotenoids containing conjugated carbonyl groups in their chains were designed to be more efficient superoxide radical scavengers than natural carotenoids, β-carotene and canthaxanthin. A practical chain-extension method for polyene dials (e.g., crocetin dial) was also proposed based on Horner-Wadsworth-Emmons olefination. Double aldol condensation between polyene dials and acetophenones with ring substituents produced oxo-carotenoids with substituted benzene rings. The antioxidant activity of oxo-carotenoids was measured using DPPH (radical) and ABTS (cationic radical) scavenging assays and compared with the analysis with the superoxide (anionic radical) probe. An effective conjugation length by carbon-carbon double bonds is important to provide superior antioxidant activity for oxo-

SUBMITTER: Shi G 

PROVIDER: S-EPMC9405038 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature