Platelet-Rich Plasma in Alopecia Areata-A Steroid-Free Treatment Modality: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

ABSTRACT:

Background

Alopecia areata (AA) is a chronic autoimmune condition that can lead to a serious deterioration in patients' quality of life. The first line of treatment in patchy AA is triamcinolone acetonide (TrA); however, the efficacy of the treatment varies greatly. Our aim was to investigate the therapeutic effects of platelet-rich plasma (PRP) in the treatment of AA.

Method

We performed a systematic literature search in four databases. Randomized clinical trials (RCT) reporting on patients with AA treated with PRP were included, comparing PRP with TrA or a placebo. The primary outcome was the Severity of Alopecia Tool (SALT) score.

Results

Our systematic search provided a total of 2747 articles. We identified four studies eligible for quantitative analysis. The pool

SUBMITTER: Meznerics FA 

PROVIDER: S-EPMC9405156 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature