Genomics of Staphylococcus aureus Strains Isolated from Infectious and Non-Infectious Ocular Conditions.

ABSTRACT: Staphylococcus aureus is a major cause of ocular infectious (corneal infection or microbial keratitis (MK) and conjunctivitis) and non-infectious corneal infiltrative events (niCIE). Despite the significant morbidity associated with these conditions, there is very little data about specific virulence factors associated with the pathogenicity of ocular isolates. A set of 25 S. aureus infectious and niCIEs strains isolated from USA and Australia were selected for whole genome sequencing. Sequence types and clonal complexes of S. aureus strains were identified by using multi-locus sequence type (MLST). The presence or absence of 128 virulence genes was determined by using the virulence finder database (VFDB). Differences between infectious (MK + conjunctivitis) and niCIE isolates from USA and

SUBMITTER: Afzal M 

PROVIDER: S-EPMC9405196 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature