DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.

ABSTRACT: Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several neurodegenerative disorders. Among the different enzymes involved in the antioxidant response, SOD1 and DJ-1 have both been associated with the pathogenesis of amyotrophic lateral sclerosis and Parkinson's disease, suggesting a possible interplay in their mechanism of action. Copper deficiency in the SOD1-active site has been proposed as a central determinant in SOD1-related neurodegeneration. SOD1 maturation mainly relies on the presence of the protein copper chaperone for SOD1 (CCS), but a CCS-independent alternative pathway also exists and functions under anaerobic condi

SUBMITTER: De Lazzari F 

PROVIDER: S-EPMC9405364 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature