Characterization of CD41⁺ cells in the lymph node.

ABSTRACT: Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells. CD41 (integrin αIIb) is known to be expressed by platelets and hematolymphoid cells. We identified two distinct populations of CD41⁺Lyve1⁺ and CD41⁺Lyve1^- cells in the LNs. CD41⁺Lyve1^- cells appear in the LN mostly at the later stages of the lives of mice. We identified CD41⁺ cells in human LNs as well. We demonstrated that murine CD41⁺ cells express mesodermal markers, such as Sca-1, CD105 and CD29, but lack platelet markers. We did not observe the presence

SUBMITTER: Dai L 

PROVIDER: S-EPMC9405417 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature