Biomarkers of Frailty: miRNAs as Common Signatures of Impairment in Cognitive and Physical Domains.

ABSTRACT: The past years have seen an increasing concern about frailty, owing to the growing number of elderly people and the major impact of this syndrome on health and social care. The identification of frail people passes through the use of different tests and biomarkers, whose concerted analysis helps to stratify the populations of patients according to their risk profile. However, their efficiency in prognosis and their capability to reflect the multisystemic impairment of frailty is discussed. Recent works propose the use of miRNAs as biological hallmarks of physiological impairment in different organismal districts. Changes in miRNAs expression have been described in biological processes associated with phenotypic outcomes of frailty, opening intriguing possibilities for their use as biomarke

SUBMITTER: Dato S 

PROVIDER: S-EPMC9405439 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature