The Hypoxia-Adenosine Link during Myocardial Ischemia-Reperfusion Injury.

ABSTRACT: Despite increasing availability and more successful interventional approaches to restore coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of morbidity and mortality worldwide. During myocardial ischemia, the myocardium becomes profoundly hypoxic, thus causing stabilization of hypoxia-inducible transcription factors (HIF). Stabilization of HIF leads to a transcriptional program that promotes adaptation to hypoxia and cellular survival. Transcriptional consequences of HIF stabilization include increases in extracellular production and signaling effects of adenosine. Extracellular adenosine functions as a signaling molecule via the activation of adenosine receptors. Several studies implicated adenosine signaling in cardioprotection, particularly through the

SUBMITTER: Ruan W 

PROVIDER: S-EPMC9405579 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature