Genomic-Analysis-Oriented Drug Repurposing in the Search for Novel Antidepressants.

ABSTRACT: From inadequate prior antidepressants that targeted monoamine neurotransmitter systems emerged the discovery of alternative drugs for depression. For instance, drugs targeted interleukin 6 receptor (IL6R) in inflammatory system. Genomic analysis-based drug repurposing using single nucleotide polymorphism (SNP) inclined a promising method for several diseases. However, none of the diseases was depression. Thus, we aimed to identify drug repurposing candidates for depression treatment by adopting a genomic-analysis-based approach. The 5885 SNPs obtained from the machine learning approach were annotated using HaploReg v4.1. Five sets of functional annotations were applied to determine the depression risk genes. The STRING database was used to expand the target genes and identify drug c

SUBMITTER: Lesmana MHS 

PROVIDER: S-EPMC9405592 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature