Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with nearly two million newly diagnosed cases each year. The survival of patients with CRC greatly depends on the cancer stage at the time of diagnosis, with worse prognosis for more advanced cases. Consequently, considerable effort has been directed towards improving population screening programs for early diagnosis and identifying prognostic markers that can better inform treatment strategies. In recent years, long non-coding RNAs (lncRNAs) have been recognized as promising molecules, with diagnostic and prognostic potential in many cancers, including CRC. Although large-scale genome and transcriptome sequencing surveys have identified many lncRNAs that are altered in CRC, most of their roles in disease onset and progr

SUBMITTER: Snyder M 

PROVIDER: S-EPMC9405614 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature