A Paradoxical Role for Regulatory T Cells in the Tumor Microenvironment of Pancreatic Cancer.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is considered to be a poorly immunogenic cancer type that combines a low mutation burden with a strong immunosuppressive tumor microenvironment. Regulatory T cells (Tregs) are major drivers of immune suppression but their prognostic role, particularly in gastrointestinal malignancies, remains controversial. Lymphocytic infiltration in 122 PDAC samples was assessed by multispectral immunofluorescence with anti-Keratin, -CD3, -CD8, -FOXP3 and -CD163 antibodies. Differential infiltration by Tregs was analyzed in the context of transcriptomic profiles that were available for 65 tumors. High infiltration of CD3⁺CD8^- (mainly CD4⁺) T cells and, especially, of the subset expressing FOXP3 (Tregs) was associated with improved p

SUBMITTER: Brouwer T 

PROVIDER: S-EPMC9405872 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature