Recurrent Glioblastoma Treatment: State of the Art and Future Perspectives in the Precision Medicine Era.

ABSTRACT: Current treatment guidelines for the management of recurrent glioblastoma (rGBM) are far from definitive, and the prognosis remains dismal. Despite recent advancements in the pharmacological and surgical fields, numerous doubts persist concerning the optimal strategy that clinicians should adopt for patients who fail the first lines of treatment and present signs of progressive disease. With most recurrences being located within the margins of the previously resected lesion, a comprehensive molecular and genetic profiling of rGBM revealed substantial differences compared with newly diagnosed disease. In the present comprehensive review, we sought to examine the current treatment guidelines and the new perspectives that polarize the field of neuro-oncology, strictly focusing on progressive

SUBMITTER: Leone A 

PROVIDER: S-EPMC9405902 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature