COBLL1 and IRS1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes.

ABSTRACT: Gestational diabetes mellitus (GDM) is carbohydrate intolerance in pregnant women leading to various complications. Currently, there is a search for factors predisposing to GDM. Among them are genetic polymorphisms of genes involved in insulin secretion as well as carbohydrate metabolism. Due to the similar pathogenesis of GDM to type 2 diabetes (T2DM), genetic polymorphisms associated with T2DM are considered. The aim of this study was to examine the associations between the COBLL1 rs7607980 T > C and IRS1 rs2943641 T > C gene polymorphisms and the risk of GDM as well as selected clinical parameters in women with GDM. Additionally, we examined the expression of these genes in the placenta of women with and without GDM in correlation with selected clinical parameters. This study included 3

SUBMITTER: Ustianowski P 

PROVIDER: S-EPMC9405993 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature