Design, Synthesis and Activity of New N¹-Alkyl Tryptophan Functionalized Dendrimeric Peptides against Glioblastoma.

ABSTRACT:

Background

Due to resistance to conventional therapy, a blood-brain barrier that results in poor drug delivery, and a high potential for metastasis, glioblastoma (GBM) presents a great medical challenge. Since the repertoire of the possible therapies is very limited, novel therapeutic strategies require new drugs as well as new approaches. The multiple roles played by L-tryptophan (Trp) in tumorigenesis of GBM and the previously found antiproliferative properties of Trp-bearing dendrimers against this malignancy prompted us to design novel polyfunctional peptide-based dendrimers covalently attached to N¹-alkyl tryptophan (Trp) residues. Their antiproliferative properties against GBM and normal human astrocytes (NHA) and their antioxidant potential were test

SUBMITTER: Sowinska M 

PROVIDER: S-EPMC9406037 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature