Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from Alismatis Rhizoma.

ABSTRACT: More than 100 protostane triterpenoids have been isolated from the dried rhizomes of Alisma species, designated Alismatis rhizoma (AR), commonly used in Asian traditional medicine to treat inflammatory and vascular diseases. The main products are the alisols, with the lead compounds alisol-A/-B and their acetate derivatives being the most abundant products in the plant and the best-known bioactive products. The pharmacological effects of Ali-A, Ali-A 24-acetate, Ali-B, Ali-B 23-acetate, and derivatives have been analyzed to provide an overview of the medicinal properties, signaling pathways, and molecular targets at the origin of those activities. Diverse protein targets have been proposed for these natural products, including the farnesoid X receptor, soluble epoxide hydrola

SUBMITTER: Bailly C 

PROVIDER: S-EPMC9406200 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature