SAR296968, a Novel Selective Na⁺/Ca²⁺ Exchanger Inhibitor, Improves Ca²⁺ Handling and Contractile Function in Human Atrial Cardiomyocytes.

ABSTRACT:

Background

In reverse-mode, cardiac sodium-calcium exchanger (NCX) can increase the cytoplasmic Ca²⁺ concentration in response to high intracellular Na⁺ levels, which may contribute to diastolic contractile dysfunction. Furthermore, increased spontaneous Ca²⁺ release from intracellular stores can activate forward mode NCX. The resulting transient inward current causes delayed afterdepolarization (DAD)-dependent arrhythmias. Moreover, recently, NCX has been associated with impaired relaxation and reduced cardiac function in heart failure with preserved ejection fraction (HFpEF). Since NCX is upregulated in human chronic atrial fibrillation (AF) as well as heart failure (HF), specific inhibition may have therapeutic potential.

Objective

We test

SUBMITTER: Hegner P 

PROVIDER: S-EPMC9406204 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature