Identification of Immune Cell Components in Breast Tissues by a Multiparametric Flow Cytometry Approach.

ABSTRACT: Immune cell components are able to infiltrate tumor tissues, and different reports described the presence of infiltrating immune cells (TILs) in several types of solid tumors, including breast cancer. The primary immune cell component cells are reported as a lymphocyte population mainly comprising the cytotoxic (CD8+) T cells, with varying proportions of helper (CD4+) T cells and CD19+ B cells, and rarely NK cells. In clinical practice, an expert pathologist commonly detects TILs areas in hematoxylin and eosin (H&E)-stained histological slides via light microscopy. Moreover, other more in-depth approaches could be used to better define the immunological component associated with tumor tissues. Using a multiparametric flow cytometry approach, we have studied the immune cells obtained from b

SUBMITTER: Coppola L 

PROVIDER: S-EPMC9406207 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature