UV₂₂₂ disinfection of SARS-CoV-2 in solution.

ABSTRACT: There is an urgent need for evidence-based engineering controls to reduce transmission of SARS-CoV-2, which causes COVID-19. Although ultraviolet (UV) light is known to inactivate coronaviruses, conventional UV lamps contain toxic mercury and emit wavelengths (254 nm) that are more hazardous to humans than krypton chlorine excimer lamps emitting 222 nm (UV₂₂₂). Here we used culture and molecular assays to provide the first dose response for SARS-CoV-2 solution exposed to UV₂₂₂. Culture assays (plaque infectivity to Vero host) demonstrated more than 99.99% disinfection of SARS-CoV-2 after a UV₂₂₂ dose of 8 mJ/cm² (pseudo-first order rate constant = 0.64 cm²/mJ). Immediately after UV₂₂₂ treatment, RT-qPCR assays targeting the

SUBMITTER: Robinson RT 

PROVIDER: S-EPMC9406255 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature