Insights into Microbiome and Metabolic Signatures of Children Undergoing Peanut Oral Immunotherapy.

ABSTRACT:

Background

Peanut oral immunotherapy has emerged as a novel, active management approach for peanut-allergic sufferers, but limited data exist currently on the role of the microbiome in successful desensitization.

Objective

We examined the oral and gut microbiome in a cohort of 17 children undergoing peanut oral immunotherapy with the aim to identify the microbiome signatures associated with successful desensitization. We also set out to characterize their fecal metabolic profiles after successful therapy.

Methods

Participants gradually built up their daily dose from 2 mg (starting dose) to 300 mg (maintenance dose) within approximately 40 weeks. We collected a buccal and stool specimen from each subject at two different time points: at baseline and post-therapy (1 mon

SUBMITTER: Blackman AC 

PROVIDER: S-EPMC9406383 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature