Expression of Functional Cannabinoid Type-1 (CB₁) Receptor in Mitochondria of White Adipocytes.

ABSTRACT: Via activation of the cannabinoid type-1 (CB₁) receptor, endogenous and exogenous cannabinoids modulate important biochemical and cellular processes in adipocytes. Several pieces of evidence suggest that alterations of mitochondrial physiology might be a possible mechanism underlying cannabinoids' effects on adipocyte biology. Many reports suggest the presence of CB₁ receptor mRNA in both white and brown adipose tissue, but the detailed subcellular localization of CB₁ protein in adipose cells has so far been scarcely addressed. In this study, we show the presence of the functional CB₁ receptor at different subcellular locations of adipocytes from epididymal white adipose tissue (eWAT) depots. We observed that CB₁ is located at differen

SUBMITTER: Pagano Zottola AC 

PROVIDER: S-EPMC9406404 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature