The Properties of Proinflammatory Ly6C^hi Monocytes Are Differentially Shaped by Parasitic and Bacterial Liver Infections.

ABSTRACT: In the past, proinflammatory CD11b⁺Ly6C^hi monocytes were predominantly considered as a uniform population. However, recent investigations suggests that this population is far more diverse than previously thought. For example, in mouse models of Entamoeba (E.) histolytica and Listeria (L.) monocytogenes liver infections, it was shown that their absence had opposite effects. In the former model, it ameliorated parasite-dependent liver injury, whereas in the listeria model it exacerbated liver pathology. Here, we analyzed Ly6C^hi monocytes from the liver of both infection models at transcriptome, protein, and functional levels. Paralleled by E. histolytica- and L. monocytogenes-specific differences in recruitment-relevant chemokines,

SUBMITTER: Hoenow S 

PROVIDER: S-EPMC9406626 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature