New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs.

ABSTRACT: The evident implication of the insulin-degrading enzyme (IDE) in Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), among its capacity to degrade insulin and amyloid-β peptide (Aβ), suggests that IDE could be an essential link in the relation between hyperinsulinemia, insulin resistance and AD. However, little is known about the cellular and molecular regulation of IDE expression, and even less has been explored regarding the post-transcriptional regulation of IDE, although it represents a great molecular target of interest for therapeutic treatments. We recently described that miR-7, a novel candidate for linking AD and T2DM at the molecular level, regulates IDE and other key genes in both pathologies, including some key genes involved in the insulin signaling pathway. Here, we

SUBMITTER: Martin-Martin Y 

PROVIDER: S-EPMC9406717 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature