Short-Chain Fatty Acids Impair Neutrophil Antiviral Function in an Age-Dependent Manner.

ABSTRACT: Half of the people living with HIV are women. Younger women remain disproportionally affected in endemic areas, but infection rates in older women are rising worldwide. The vaginal microbiome influences genital inflammation and HIV infection risk. Multiple factors, including age, induce vaginal microbial alterations, characterized by high microbial diversity that generate high concentrations of short-chain fatty acids (SCFAs), known to modulate neutrophil function. However, how SCFAs may modulate innate anti-HIV protection by neutrophils is unknown. To investigate SCFA-mediated alterations of neutrophil function, blood neutrophils from younger and older women were treated with SCFAs (acetate, butyrate and propionate) at concentrations within the range reported during bacterial vaginosis, a

SUBMITTER: Carrillo-Salinas FJ 

PROVIDER: S-EPMC9406757 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature