Neonatal Platelets: Lower G_12/13 Expression Contributes to Reduced Secretion of Dense Granules.

ABSTRACT: Despite fully functional primary hemostasis, platelets of healthy neonates exhibit hypoaggregability and secretion defects, which may be adaptations to specific requirements in this developmental stage. The etiologies for reduced signal transduction vary with the type of agonist. The discovered peculiarities are lower receptor densities, reduced calcium mobilization, and functional impairments of G proteins. Reduced secretion of dense granules has been attributed to lower numbers of granules. Signaling studies with adult platelets have shown a regulating effect of the G_12/13 signaling pathway on dense granule secretion via RhoA. We comparatively analyzed secretion profiles using flow cytometry and expression levels of G_q, G_i, and G_12/13 using Wes

SUBMITTER: Schlagenhauf A 

PROVIDER: S-EPMC9406762 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature