Recent Advances in the Modulation of Pain by the Metabotropic Glutamate Receptors.

ABSTRACT: Metabotropic glutamate receptors (mGluR or mGlu) are G-protein coupled receptors activated by the binding of glutamate, the main classical neurotransmitter of the nervous system. Eight different mGluR subtypes (mGluR1-8) have been cloned and are classified in three groups based on their molecular, pharmacological and signaling properties. mGluRs mediate several physiological functions such as neuronal excitability and synaptic plasticity, but they have also been implicated in numerous pathological conditions including pain. The availability of new and more selective allosteric modulators together with the canonical orthosteric ligands and transgenic technologies has led to significant advances in our knowledge about the role of the specific mGluR subtypes in the pathophysiological mechanis

SUBMITTER: Mazzitelli M 

PROVIDER: S-EPMC9406805 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature