Unknown

Dataset Information

0

Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson's Disease.


ABSTRACT: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Investigating individuals with the most identical genetic background is optimal for minimizing the genetic contribution to gene expression. These individuals include monozygotic twins discordant for PD. Monozygotic twins have the same genetic background, age, sex, and often similar environmental conditions. The aim of this study was to carry out a transcriptome analysis of the peripheral blood of three pairs of monozygotic twins discordant for PD. We identified the metabolic process "circadian behavior" as a priority process for further study. Different expression of genes included in the term "circadian behavior" confirms that this process is involved in PD pathogenesis. We found increased expression of three genes associated with circadian behavior, i.e., PTGDS, ADORA2A, and MTA1, in twins with PD. These genes can be considered as potential candidate genes for this disease.

SUBMITTER: Semenova EI 

PROVIDER: S-EPMC9406852 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson's Disease.

Semenova Ekaterina I EI   Vlasov Ivan N IN   Partevian Suzanna A SA   Rosinskaya Anna V AV   Rybolovlev Ivan N IN   Slominsky Petr A PA   Shadrina Maria I MI   Alieva Anelya Kh AK  

Cells 20220820 16


Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Investigating individuals with the most identical genetic background is optimal for minimizing the genetic contribution to gene expression. These individuals include monozygotic twins discordant for PD. Monozygotic twins have the same genetic background, age, sex, and often similar environmental conditions. The aim of this study was to carry out a transcriptome analysis of the peripheral blood of three pairs of monozy  ...[more]

Similar Datasets

2022-08-22 | GSE208347 | GEO
| PRJNA859516 | ENA
| S-EPMC7222158 | biostudies-literature
| S-EPMC2830382 | biostudies-literature
| S-EPMC11836399 | biostudies-literature
| S-EPMC4255586 | biostudies-literature
| S-EPMC2257994 | biostudies-other
| S-EPMC8700621 | biostudies-literature
| S-EPMC3760303 | biostudies-literature
| S-EPMC6547746 | biostudies-literature