M⁶A Methylation Regulators Are Predictive Biomarkers for Tumour Metastasis in Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) is one of the most common cancers in men. Usually, most PCas at initial diagnosis are localized and hormone-dependent, and grow slowly. Patients with localized PCas have a nearly 100% 5-year survival rate; however, the 5-year survival rate of metastatic or progressive PCa is still dismal. N6-methyladenosine (m⁶A) is the most common post-transcriptional mRNA modification and is dynamically regulated by m⁶A regulators. A few studies have shown that the abnormal expression of m⁶A regulators is significantly associated with cancer progression and immune cell infiltration, but the roles of these regulators in PCa remain unclear. Here, we examined the expression profiles and methylation levels of 21 m⁶A regulators across the Cance

SUBMITTER: Liang Y 

PROVIDER: S-EPMC9406868 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature