The Interaction of Human Papillomavirus Infection and Prostaglandin E₂ Signaling in Carcinogenesis: A Focus on Cervical Cancer Therapeutics.

ABSTRACT: Chronic infection by high-risk human papillomaviruses (HPV) and chronic inflammation are factors associated with the onset and progression of several neoplasias, including cervical cancer. Oncogenic proteins E5, E6, and E7 from HPV are the main drivers of cervical carcinogenesis. In the present article, we review the general mechanisms of HPV-driven cervical carcinogenesis, as well as the involvement of cyclooxygenase-2 (COX-2)/prostaglandin E₂ (PGE₂) and downstream effectors in this pathology. We also review the evidence on the crosstalk between chronic HPV infection and PGE₂ signaling, leading to immune response weakening and cervical cancer development. Finally, the last section updates the current therapeutic and preventive options targeting PGE_2</

SUBMITTER: Garcia-Quiroz J 

PROVIDER: S-EPMC9406919 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature