Sema4C Is Required for Vascular and Primary Motor Neuronal Patterning in Zebrafish.

ABSTRACT: Endothelial cells (ECs) and neurons share a number of common signaling pathways and molecular mediators to orchestrate directional migration and guide the pattern of the vascular network and nervous system. So far, research concerning the functional coupling between vascular and neuronal pathfinding remains insufficient. Semaphorin4C (sema4C), a member of class 4 semaphorins, is initially described in the nervous system, whose role has been demonstrated in diverse biological developments. The present study focused on the role of sema4C in the vascular and neural development process in zebrafish embryos. It confirmed that sema4C is expressed in both the nervous system and intersegmental vessels (ISVs) in zebrafish embryos by diverse expression analysis. It also showed that the

SUBMITTER: Sheng J 

PROVIDER: S-EPMC9406964 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature