Expression of CD44 in Leukocyte Subpopulations in Patients with Inflammatory Bowel Diseases.

ABSTRACT: CD44 expressed in monocytes and lymphocytes seems to play a crucial role in gastrointestinal inflammation, such as the one occurring in the context of inflammatory bowel diseases. Differentially methylated genes are distinctly expressed across monocyte subpopulations related to the state of Crohn's disease. Hence, the aim of this study was to detect CD44 expression in leukocyte subpopulations in relation to the type of IBD, therapy, and disease duration. Monocyte subpopulations CD14⁺⁺CD16^-, CD14⁺⁺CD16⁺⁺, and CD14⁺CD16⁺ as well as other leukocytes were analyzed for their CD44 expression using flow cytometry in 46 patients with IBD and 48 healthy controls. Patients with Crohn's disease treated with non-biological therapy (NBT)

SUBMITTER: Franic I 

PROVIDER: S-EPMC9407096 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature