Gene expression signatures and cardiometabolic outcomes following 8-week mango consumption in individuals with overweight/obesity.

ABSTRACT:

Background

Little is known about the impact of mango consumption on metabolic pathways assessed by changes in gene expression.

Methods

In this single-arm clinical trial, cardiometabolic outcomes and gene expression levels in whole blood samples from 26 men and women were examined at baseline and after 8 weeks of mango consumption and differential gene expression changes were determined. Based on changes in gene expression profiles, partial least squares discriminant analysis followed by hierarchical clustering were used to classify participants into subgroups of response and differences in gene expression changes and in cardiometabolic clinical outcomes following the intervention were tested.

Results

Two subgroups of participants were separated based on the resemblanc

SUBMITTER: Keathley J 

PROVIDER: S-EPMC9407242 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature