Sorting of mitochondrial and plastid heteroplasmy in <i>Arabidopsis</i> is extremely rapid and depends on MSH1 activity.

ABSTRACT: The fate of new mitochondrial and plastid mutations depends on their ability to persist and spread among the numerous organellar genome copies within a cell (heteroplasmy). The extent to which heteroplasmies are transmitted across generations or eliminated through genetic bottlenecks is not well understood in plants, in part because their low mutation rates make these variants so infrequent. Disruption of MutS Homolog 1 (MSH1), a gene involved in plant organellar DNA repair, results in numerous de novo point mutations, which we used to quantitatively track the inheritance of single nucleotide variants in mitochondrial and plastid genomes in Arabidopsis. We found that heteroplasmic sorting (the fixation or loss of a variant) was rapid for both organelles, greatly exceed

SUBMITTER: Broz AK 

PROVIDER: S-EPMC9407294 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature