The Cannabis-Induced Epigenetic Regulation of Genes Associated with Major Depressive Disorder.

ABSTRACT: The prevalence of depression is increasing worldwide, as is the number of people suffering from treatment-resistant depression; these patients constitute 30% of those treated. Unfortunately, there have not been significant advances in the treatment of this disorder in the past few decades. Exposure to cannabis and cannabis-derived compounds impacts depression symptomatology in different ways, with evidence indicating that cannabidiol has antidepressant effects; there have been mixed results with medical cannabis. Even though the exact molecular mechanisms of the action underlying changes in depression symptomatology upon exposure to cannabis and cannabis-derived compounds are still unknown, there is strong evidence that these agents have a widespread impact on epigenetic regulation. We hyp

SUBMITTER: Mohammad GS 

PROVIDER: S-EPMC9407536 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature