Ontology highlight
ABSTRACT:
SUBMITTER: Webb JM
PROVIDER: S-EPMC9407645 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Webb John M JM Ma Mingyang M Yin Chen C Ptáček Louis J LJ Fu Ying-Hui YH
Proceedings of the National Academy of Sciences of the United States of America 20220728 34
Sleep is a necessity for our survival, but its regulation remains incompletely understood. Here, we used a human sleep duration gene to identify a population of cells in the peri-tegmental reticular nucleus (pTRN<sup>ADRB1</sup>) that regulate sleep-wake, uncovering a role for a poorly understood brain area. Although initial ablation in mice led to increased wakefulness, further validation revealed that pTRN<sup>ADRB1</sup> neuron stimulation strongly promotes wakefulness, even after stimulation ...[more]