The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women.

ABSTRACT: Polygenic susceptibility likely influences individual responses to air pollutants and the risk of asthma. We compared the role of polygenic susceptibility on air pollution-associated asthma between German and Japanese women. We investigated women that were enrolled in the German SALIA cohort (n = 771, mean age = 73 years) and the Japanese Shika cohort (n = 847, mean age = 67 years) with known asthma status. Adjusted logistic regression models were used to assess the associations between (1) particulate matter with a median aerodynamic diameter ≤ 2.5μm (PM_2.5) and nitrogen dioxide (NO₂), (2) polygenic risk scores (PRS), and (3) gene-environment interactions (G × E) with asthma. We found an increased risk of asthma in Japanese women after exposure to low pollutant level

SUBMITTER: Kress S 

PROVIDER: S-EPMC9407879 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature