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The Clinical Significance of Urinary Retinol-Binding Protein 4: A Review.


ABSTRACT: Effective biomarkers for early diagnosis, prognostication, and monitoring in renal diseases (in general) comprise an unmet need. Urinary retinol-binding protein 4, which is the most sensitive indicator of renal tubular damage, holds great promise as a universal biomarker for renal pathologies, in which tubular injury is the driving force. Here, we summarize the most important existing data on the associations between urinary retinol-binding protein 4 and renal diseases and highlight the untapped potential of retinol-binding protein 4 in clinical use.

SUBMITTER: Ratajczyk K 

PROVIDER: S-EPMC9408023 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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The Clinical Significance of Urinary Retinol-Binding Protein 4: A Review.

Ratajczyk Krzysztof K   Konieczny Andrzej A   Czekaj Adrian A   Piotrów Paweł P   Fiutowski Marek M   Krakowska Kornelia K   Kowal Paweł P   Witkiewicz Wojciech W   Marek-Bukowiec Karolina K  

International journal of environmental research and public health 20220811 16


Effective biomarkers for early diagnosis, prognostication, and monitoring in renal diseases (in general) comprise an unmet need. Urinary retinol-binding protein 4, which is the most sensitive indicator of renal tubular damage, holds great promise as a universal biomarker for renal pathologies, in which tubular injury is the driving force. Here, we summarize the most important existing data on the associations between urinary retinol-binding protein 4 and renal diseases and highlight the untapped  ...[more]

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