Prediction of Synaptically Localized RNAs in Human Neurons Using Developmental Brain Gene Expression Data.

ABSTRACT: In the nervous system, synapses are special and pervasive structures between axonal and dendritic terminals, which facilitate electrical and chemical communications among neurons. Extensive studies have been conducted in mice and rats to explore the RNA pool at synapses and investigate RNA transport, local protein synthesis, and synaptic plasticity. However, owing to the experimental difficulties of studying human synaptic transcriptomes, the full pool of human synaptic RNAs remains largely unclear. We developed a new machine learning method, called PredSynRNA, to predict the synaptic localization of human RNAs. Training instances of dendritically localized RNAs were compiled from previous rodent studies, overcoming the shortage of empirical instances of human synaptic RNAs. Using RNA sequ

SUBMITTER: Wei A 

PROVIDER: S-EPMC9408096 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature