Internal Validation of MaSTR™ Probabilistic Genotyping Software for the Interpretation of 2-5 Person Mixed DNA Profiles.

ABSTRACT: Mixed human deoxyribonucleic acid (DNA) samples present one of the most challenging pieces of evidence that a forensic analyst can encounter. When multiple contributors, stochastic amplification, and allele drop-out further complicate the mixture profile, interpretation by hand becomes unreliable and statistical analysis problematic. Probabilistic genotyping software has provided a tool to address complex mixture interpretation and provide likelihood ratios for defined sets of propositions. The MaSTR™ software is a fully continuous probabilistic system that considers a wide range of STR profile data to provide likelihood ratios on DNA mixtures. Mixtures with two to five contributors and a range of component ratios and allele peak heights were created to test the validity of MaSTR™ with dat

SUBMITTER: Adamowicz MS 

PROVIDER: S-EPMC9408203 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature