ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells.

ABSTRACT: ACBD3 overexpression has previously been found to correlate with worse prognosis for breast cancer patients and, as an incredibly diverse protein in both function and cellular localisation, ACBD3 may have a larger role in breast cancer than previously thought. This study further investigated ACBD3's role in breast cancer. Bioinformatic databases were queried to characterise ACBD3 expression and mutation in breast cancer and to investigate how overexpression affects breast cancer patient outcomes. Immunohistochemistry was carried out to examine ACBD3 location within cells and tissue structures. ACBD3 was more highly expressed in breast cancer than in any other cancer or matched normal tissue, and expression over the median level resulted in reduced relapse-free, overall

SUBMITTER: Houghton-Gisby J 

PROVIDER: S-EPMC9408326 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature