Functional Expression of Choline Transporters in Microglia and Their Regulation of Microglial M1/M2 Polarization.

ABSTRACT:

Background

Microglia are key cells of the immune system in the central nervous system and are suggested to be deeply involved in the development of neurodegenerative diseases. It is well known that microglia have functional plasticity, with an inflammatory M1 phenotype and an anti-inflammatory M2 phenotype. Inhibition of choline transport in macrophages has been reported to suppress the secretion of inflammatory cytokines. However, the role of the choline transport system in regulating microglial M1/M2 polarization has not been fully elucidated to date. In this study, we investigated the mechanism of choline uptake in microglia, and its association with microglial M1/M2 polarization.

Methods

The immortalized mouse microglial cell line SIM-A9 was used for [³H]choli

SUBMITTER: Okada T 

PROVIDER: S-EPMC9408370 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature