TTN Variants Are Associated with Physical Performance and Provide Potential Markers for Sport-Related Phenotypes.

ABSTRACT: TTN encodes the third myofilament, titin, which plays structural, mechanical, regulatory, and developmental roles in sarcomeres. The aim of this research was to determine the interaction between novel and previously described TTN variants and athletic performance, as well as competition level, in Caucasians. Firstly, 100 athletes and 47 controls were recruited, and whole-genome sequencing was performed. Secondly, 348 athletes (108 endurance, 100 sprint/power, 140 mixed-sport athletes) and 403 volunteers were included, and real-time PCR was performed. We found a significant overrepresentation of the rs10497520 CT and TT genotypes in the sprint/power athlete group (95% CI, 1.41-3.66, p = 0.0013). The rs10497520 T carriers were 2.17 times more likely to become sprint/powe

SUBMITTER: Leonska-Duniec A 

PROVIDER: S-EPMC9408402 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature