New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation.

ABSTRACT: The current study describes the synthesis, physicochemical characterization and cytotoxicity evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules. The new pyrroles were obtained by reaction of benzimidazolium bromide derivatives with asymmetrical acetylenes in 1,2-epoxybutane under reflux through the Huisgen [3 + 2] cycloaddition of several ylide intermediates to the corresponding dipolarophiles. The intermediates salts were obtained from corresponding benzimidazole with bromoacetonitrile. The structures of the newly synthesized compounds were confirmed by elemental analysis, spectral techniques (i.e., IR, ¹H-NMR and ¹³C-NMR) and single-crystal X-ray analysis. The cytotoxicity of the synthesized compounds was evaluated on plan

SUBMITTER: Ivan BC 

PROVIDER: S-EPMC9408590 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature