Ontology highlight
ABSTRACT:
SUBMITTER: Lemarchant S
PROVIDER: S-EPMC9408760 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Lemarchant Sighild S Sourioux Mélissa M Le Douce Juliette J Henriques Alexandre A Callizot Noëlle N Hugues Sandrine S Farinelli Mélissa M Godfrin Yann Y
International journal of molecular sciences 20220809 16
NX210c is a disease-modifying dodecapeptide derived from the subcommissural organ-spondin that is under preclinical and clinical development for the treatment of neurological disorders. Here, using whole-cell patch-clamp recordings, we demonstrate that NX210c increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)- and GluN2A-containing N-methyl-D-aspartate receptor (GluN2A-NMDAR)-mediated excitatory postsynaptic currents in the brain. Accordingly, using extracellular fie ...[more]