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Nervous System-Driven Osseointegration.

ABSTRACT: Implants are essential therapeutic tools for treating bone fractures and joint replacements. Despite the in-depth study of osseointegration for more than fifty years, poor osseointegration caused by aseptic loosening remains one of the leading causes of late implant failures. Osseointegration is a highly sophisticated and spatiotemporal process in vivo involving the immune response, angiogenesis, and osteogenesis. It has been unraveled that the nervous system plays a pivotal role in skeletal health via manipulating neurotrophins, neuropeptides, and nerve cells. Herein, the research related to nervous system-driven osseointegration was systematically analyzed and reviewed, aiming to demonstrate the prominent role of neuromodulation in osseointegration. Additionally, it is indicated that the implant design considering the role of neuromodulation might be a promising way to prevent aseptic loosening.

SUBMITTER: Sun R

PROVIDER: S-EPMC9408825 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Nervous System-Driven Osseointegration.

Sun Ruoyue R Bai Long L Yang Yaru Y Ding Yanshu Y Zhuang Jingwen J Cui Jingyuan J

International journal of molecular sciences 20220810 16

Implants are essential therapeutic tools for treating bone fractures and joint replacements. Despite the in-depth study of osseointegration for more than fifty years, poor osseointegration caused by aseptic loosening remains one of the leading causes of late implant failures. Osseointegration is a highly sophisticated and spatiotemporal process in vivo involving the immune response, angiogenesis, and osteogenesis. It has been unraveled that the nervous system plays a pivotal role in skeletal hea ...[more]

PMID: 36012155

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