Association of Antihypertensive Effects of Esaxerenone with the Internal Sodium Balance in Dahl Salt-Sensitive Hypertensive Rats.

ABSTRACT:

Background

The nonsteroidal mineralocorticoid receptor blocker esaxerenone is effective in reducing blood pressure (BP).

Objective

In this study, we investigated esaxerenone-driven sodium homeostasis and its association with changes in BP in Dahl salt-sensitive (DSS) hypertensive rats.

Methods

In the different experimental setups, we evaluated BP by a radiotelemetry system, and sodium homeostasis was determined by an approach of sodium intake (food intake) and excretion (urinary excretion) in DSS rats with a low-salt diet (0.3% NaCl), high-salt diet (HSD, 8% NaCl), HSD plus 0.001% esaxerenone (w/w), and HSD plus 0.05% furosemide.

Results

HSD-fed DSS rats showed a dramatic increase in BP with a non-dipper pattern, while esaxerenone treatment, but n

SUBMITTER: Hattori M 

PROVIDER: S-EPMC9408866 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature